ABSTRACT
Aim: To assess the neurological and mental health responses to pandemic Covid-19. Study design: Cohort study Place and duration of study: Department of Medicine, Chandka Medical College Hospital Larkana and Department of Medicine, Khairpur Medical College Hospital Khairpur Mir's from 1st October 2021 to 31st March 2022. Methodology: Two hundred patients who suffered Covid-19 infection and 200 who had any other life event except Covid-19 were enrolled. All patients who were above 18 years of age and were positive for Covid-19 through reverse transcriptase PCR were included in the study.Global Psych trauma Screening was done by enlisting twenty-two items which assessed trauma related symptoms while five items only assessed the factors increasing risks. Result(s): There were 112 (56%) females and 88 (44%) males in Covid-19 patients and 150 (75%) females and 50 (25%) males in non-Covid patients. The mean age of the Covid-19 patients was 49.65+/-15.5 year while of non Covid patients was 39.02+/-12.01 years. A significant increase in post-traumatic stress disorder (PTSD) cases probability was noted in the Covid-19 cases than non Covid-19 related events. Neurological responses showed that patients who had suffered from Covid 19 infections had a generalized weakness with hyposmia formation. Conclusion(s): Covid-19 is related with high level of depression, anxiety, hyposmia and other mental and neurological responses. Copyright © 2022 Lahore Medical And Dental College. All rights reserved.
ABSTRACT
Aim: To determine the frequency of severe vitamin D deficiency and its association with mortality in patients presented with Covid-19. Study Design: Cross-sectional/Observational Place and Duration of Study: Chandka Medical College Hospital, Larkana and Gambat Medical College Hospital, Gambat from 1st March 2020 to 31st August 2020 Methodology: One hundred and twenty five patients of both genders diagnosed to have severe covid-19 disease by real time PCR were analyzed. Patient’s ages were ranging from 15 years to 70 years. Detailed demographics were recorded after taking written consent. 5 ml blood sample was taken from all the patients to examine the vitamin D level. Severe Vitamin D deficiency was defined as 25(OH)D <25 nmol/L (10 ng/dL). Association between mortality and severe vitamin D deficiency was examined. Results: Seventy five (60%) were males while 50 (40%) were females with mean age 45.58±15.66 years. Severe vitamin D deficiency was observed in 57 (45.6%) patients. Overall mortality was found in 14 (11.2%) patients, Among 57 patients with severe vitamin D deficiency 12 (9.6%) were died while patients with no vitamin D deficiency 2/68 (1.6%), a significant association was observed between severe vitamin D deficiency and mortality in patients with covid-19 disease with p-value <0.05. Conclusion: There was strong relationship between severe vitamin-D deficiency and mortality in patients with covid-19 disease. © 2020 Lahore Medical And Dental College. All rights reserved.